GS-004 Leto gene optimization

The Leto gene optimization software package has been developed at the Entelechon bioinformatics unit over more than eight years. Leto uses a genetic algorithm which allows for a multi-objective optimization of gene sequences for maximum expression yields.

Expertise based on many years of gene optimization and customer feedback have continuously been incorporated into this software. Leto’s advanced optimization algorithm allows it to search the vast space of possible codon permutations for a DNA sequence that optimally meets a number of important criteria, such as codon usage, mRNA secondary structure, avoidance of splice sites or mRNA stability.

Leto benefits include:

• Set of 15 optimization parameters with a direct impact on the expression yield
• Up-to-date and species-specific splice site prediction
• Simultaneous optimization for multiple target organisms
• Implementation of custom parameters or requirements
• Detailed documentation and consulting availableLeto

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