Entelechon offers codon-precision mutation libraries

Based on an innovative new technology developed in-house at Entelechon, we offer codon-precision mutation libraries effective immediately. These libraries contain randomized positions where a set of multiple alternative codons is incorporated into the gene sequence.

As opposed to conventional randomized gene libraries, codon-precision libraries are not based on single nucleotide wobbles. Therefore, they avoid the typical problem of undesired codon variants or stop codons.

With Entelechon’s codon-precision libraries, the combination and ratio of codons at a particular sequence position can be specified by the customer. By avoiding undesired variants, these libraries have a significantly reduced complexity and can potentially save a lot of labor and costs in the screening process. They are ideally suited for:

Alanine scanning
Antibody maturation
Protein engineering
Enzyme design

For more information, please see our website.